Ethnobotanical and Pharmacological Study of Ampelozizyphus amazonicus Ducke (Rhamnaceae)

a Review

Authors

  • Inês Ribeiro Machado Universidade Estadual do Norte Fluminense Darcy Ribeiro/UENF. Avenida Alberto Lamego, 2000, Parque Califórnia, Campos dos Goytacazes/ RJ. Brasil
  • Keila Rêgo Mendes Instituto Chico Mendes de Conservação da Biodiversidade/ICMBio. EQSW 103/104, Bloco "B", Complexo Administrativo, Setor Sudoeste, Brasilia/DF, Brasil

DOI:

https://doi.org/10.37002/biodiversidadebrasileira.v11i1.1785

Keywords:

Saracura-mirá therapeutic activity, indian beer ethnobotany, pharmacological properties of curupiramirá beer

Abstract

Ampelozizyphus amazonicus, popularly known as "saracura-mirá", belongs the family plants Rhamnaceae. This plant it has limited occurrence to the of the Amazon region and have showing numerous ethnobotanical and pharmacological properties. In this review, among the pharmacological properties found are antiviral, antibacterial and antifungal, trypanocidal, antimalarial, larvicidal, immunobiological and anti-inflammatory, diuretic and antidiuretic, cytotoxic and antitumor, adaptogenic and immunomodulatory activities. Metabolites related to antiviral, antibacterial and antifungal activity were not found in the literature. The metabolites betulinic acid, 3ß-hydroxylup-20 (29) -eno-27,28-diioic acid and 2T, 3ß-dihydroxylup-20 (29) -eno-27,28 were found in the methanolic and ethyl acetate extract. -dioecious. For antimalarial and larvicidal activity, no metabolites were found for such activities. Complex saponins present in the aqueous extract were related to immunobiological and anti-inflammatory activities. Saponins and triterpenes mixed with saponins from the ethanolic extract of dry roots were related to diuretic and antidiuretic activity. The compounds 3ß-hydroxilup-20 (29) -en-27, 28-dioic acid and 2T, 3ß-dihydroxilup-20 (29) -eno-27,28-dioic acid found in the crude extract of hexane, ethyl- acetate, ethanolic, methanolic and aqueous from A. amazonicus demonstrated cytotoxic and antitumor activity. No compounds related to adaptogenic and immunomodulatory activity were found. The present work reviewed the ethnobotanical and pharmacological properties of Ampelozizyphus amazonicus.

References

Almeida ER. 1993. Brazilian medicinal plants. Popular and scientific knowleadge. Editora Helmus, São Paulo, Brasil. 341p.

Amaral ACF et al. Updated studies on Ampelozizyphus amazonicus, a medicinal plant used in the Amazonian Region. Pharmacognosy Reviews, 2(4): 308-316, 2008.

Andrade-Neto VF, Brandão MG, Nogueira F, Rosário VE & Krettli AU. Ampelozyziphus amazonicus Ducke (Ramnaceae), a medicinal plant used to prevent malaria in the Amazon Region, hampers the development of Plasmodium berghei sporozoites. The International Journal for Parasitology, 38(13): 1505-1511, 2008.

Berg ME. 1993. Medicinal plants in the Amazon: contribution to its systematic use. Revista do Museu paraense Emílio Goeldi, Belém, Pará. 207p.

Brandão MGL, Lacaille-Dubois MA, Teixeira MA & Wagner H. A dammarane-type saponin from the roots of Ampelozizyphus amazonicus. Phytochemistry, 34: 1123-1127, 1993.

Brandão MGL, Lacalle-Dubois MA, Teixeira MA & Wagner H. Triterpene saponins from the roots of Ampelozizyphus amazonicus. Phytochemistry, 31(1): 352-354, 1992.

Brandão MGL, Botelho MGA & Krettli A.U. Experimental antimalarial chemotherapy with natural products: A more rational approach? Ciência e Cultura, 37: 1152-1163, 1985.

Chang CH, Lin CC, Yang JJ, Namba T & Hattori M. Anti-inflammatory effects of emodin from Ventilago leiocarpa. American Journal of Chinese Medicine, 24: 139-142, 1996.

Coelho-Ferreira MR. 1992. Les Plantes Médicinales à Manaus: utilisation et commercialisation. In: DESU de Biologie Végétale Tropicale. Paris: Iniversité Paris 6. 60p.

Diniz LRL et al. Effect of triterpene saponins from roots of Ampelozizyphus amazonicus Ducke on diuresis inrats. Journal of Ethnopharmacology, 123(2): 275-279, 2009.

Diniz LRL et al. The effect of saponins from Ampelozizyphus amazonicus Ducke on the renal Na+pumps' activities and urinary excretion of natriureticpeptides. BMC Complementary and Alternative Medicine, 12(40): 1-7, 2012.

Diniz LRL. 2006. Efeito das saponinas triterpênicas isoladas de raízes da Ampelozizyphus amazonicusDucke sobre a função renal. Dissertação (Mestrado em Ciências Biológicas). Universidade Federal de Minas Gerais. 116p.

Ducke JA & Martinez RV. 1994. Amazonian Ethnobotanical Dictionary. CRC Press, Boca Raton, USA. 215p.

Dultra M. Saracura-mirá a planta eficaz. Belém, 21/11/93. Jornal O Liberal.

Hidalgo AF. 2003. Plantas de uso popular para o tratamento da malária e males associados da área de influência do Rio Solimões e Região de Manaus, AM. Tese (Doutorado em Horticultura). Universidade Estadual Paulista. 202p.

Institute de Recherce pour le Développement. Lespharmacopées traditionnelles: quel rôle dans la lutte contre Le paludisme? Disponível em: <http://www.ird. fr/fr/actualites/dossiers/dp_paludisme_25avril08.pdf>. Acesso em: 28/09/ 2008.

Khan MTH, Ather A, Thompson KD & Gambari R. Extracts and molecules from medicinal plants against herpes simplex viruses. Antiviral Research, 67: 107-119, 2005.

Kim MK, Lee SE & Lee HS. Growth-inhibiting effects of Brazilian and Oriental medicinal plants on human intestinal bacteria. Agricultural Chemistry and Biotechnology, 43: 54-58, 2000.

Krettli AU, Andrade Neto VF, Brandão MGL & Ferrari WMS. The search for new antimalarial drugs from plants used to treat fever and malaria or plants ramdomly selected: a review. Memórias do Instituto Oswaldo Cruz, 96(8): 1033-1042, 2001.

Krettli AU & Andrade-Neto VF. Search antimalarial drugs in the folk medicine. Ciência Hoje, 35: 70-73, 2004.

Krettli AU. 2003. Progressos e dificuldades em Etnofarmacologia visando a pesquisas de novos antimaláricos. In: Brandão MGL (org.). Plantas medicinais & fitoterapia. Belo Horizonte: Faculdade de Farmácia, 4p.

Krettli, AU & Andrade-NetoVF. Search antimalarial drugs in the folk medicine. Ciência Hoje, 35: 70-73, 2004.

Le Cointe P. 1947. Amazônia brasileira. III - Árvores e Plantas Úteis (indígenas e aclimatadas). Ed. Nacional, São Paulo. 506p.

Lima RB. Flora da reserva Ducke, Amazonas, Brasil: Rhamnaceae. Rodriguésia, 57: 247-249, 2006.

Lopez A, Hudson JB & Towers GHN. Antiviral and antimicrobial activities of Colombian medicinal plants. Journal of Ethnopharmacology, 77: 189-196, 2001.

Sparg SG, Light ME & Van Staden J. Biological activities and distribution of plant saponins. Journal of Ethnopharmacology, 94: 219-243, 2004.

Vieira LS. 1992. Amazonian phytotherapy. Editora Agronômica Ceres, São Paulo, Brasil. 347p.

Young-Su J, Moo-Key K, Young-Joon A & Hoi-Seon L. Larvicidal Activity of Brazilian Plants against Aedes aegypti and Culex pipiens pallens (Diptera: Culicidae). Journal of Agricutural Chemistry Biotechnology, 45(3): 131-134, 2002.

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Published

2021-06-02

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